2.13 Begin the Begin

Dr. Webber enforces an 80 hour per week maximum rule for the interns. Derek wants to enroll Ellis in a experimental treatment for Alzheimer's, but Meredith doesn't want his help and Derek needs Dr. Webber to intervene. Izzie seems to be getting over Alex when she shares an undeniable chemistry with Denny Duquette, a patient awaiting a heart transplant. Bailey goes to retrieve Denny's heart, taking Cristina along for the ride. Meanwhile George and Addison treat Bex, a young teen hermaphrodite.